Peripheral Neuropathy & Neuromuscular Disorders
Peripheral neuropathy and neuromuscular disorders encompass a broad spectrum of conditions affecting the peripheral nerves, neuromuscular junctions, and skeletal muscles. Peripheral neuropathies may arise from diabetes, infections, autoimmune diseases, toxins, or hereditary conditions, causing sensory disturbances, weakness, pain, and autonomic dysfunction. Neuromuscular disorders include myasthenia gravis, muscular dystrophies, amyotrophic lateral sclerosis, and congenital myopathies. Diagnosis involves clinical examination, electrophysiological testing (EMG, nerve conduction studies), genetic testing, muscle biopsy, and imaging when indicated. Management is tailored to the underlying etiology and often includes pharmacotherapy, immunotherapy, physical therapy, occupational therapy, and supportive interventions. Advances in genetic testing and molecular diagnostics have improved identification of inherited neuromuscular disorders, enabling targeted therapies and early intervention. Emerging treatments include gene therapy, enzyme replacement, and stem cell approaches, offering hope for disease modification and functional improvement. Rehabilitation focuses on preserving strength, mobility, and quality of life. Multidisciplinary care, including neurologists, physiatrists, therapists, and nutritionists, is essential for optimal outcomes. Research continues to explore pathophysiological mechanisms, novel therapeutic strategies, and biomarkers for early detection and monitoring. Peripheral neuropathy and neuromuscular disorders highlight the complexity of the neuromuscular system and the need for integrated clinical care, technological innovation, and patient-centered approaches to enhance function, independence, and well-being.
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