Traumatic Brain Injury & Concussion
Traumatic brain injury (TBI) and concussion represent a major public health concern worldwide, resulting from external mechanical forces impacting the brain. These injuries range from mild concussions to severe brain damage, leading to cognitive, motor, sensory, and emotional impairments. The pathophysiology of TBI involves primary injury from mechanical forces and secondary injury caused by neuroinflammation, oxidative stress, excitotoxicity, and blood-brain barrier disruption. Concussions, a mild form of TBI, are often underdiagnosed yet can have significant short- and long-term consequences, including post-concussion syndrome and increased susceptibility to neurodegenerative diseases. Diagnosis relies on clinical evaluation, neuroimaging, and neurocognitive assessment, often supplemented by biomarkers for neuronal injury. Management is multidisciplinary, focusing on acute stabilization, symptom management, cognitive rehabilitation, physical therapy, and psychological support. Emerging technologies, such as wearable sensors, AI-driven predictive models, and virtual reality-based rehabilitation, improve assessment, monitoring, and functional recovery. Research emphasizes understanding injury mechanisms, identifying biomarkers, optimizing early intervention, and preventing long-term sequelae. Education on injury prevention, return-to-play protocols in sports, and workplace safety measures is critical. The ultimate goal is to minimize functional impairment, enhance neuroplasticity, and promote optimal recovery, making TBI and concussion care a dynamic intersection of neurology, rehabilitation, and technology.
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